人肺腺癌細胞株A549
MG-63人成骨肉瘤細胞株
Saos-2人成骨肉瘤細胞株
SW1353人骨肉瘤細胞株
推薦培養(yǎng)基:（FM, Cat. No. 2301）

儲存：液氮

運輸：干冰

用途：科研

The most abundant cell type in lung interstitium is fibroblasts. They resemble ordinary fibroblasts but have some distinguishing features, for example, they have long branching processes ａnd gap junctions. Their principle function is production of type III collagen, elastin, ａnd proteoglycans of the extracellular matrix of the alveolar septa. Pulmonary fibroblasts （PF） play an important role in the repair ａnd remodeling processes following injury. The controlled accumulation of fibroblasts to sites of inflammation is crucial to effective tissue repair after injury [1]. Either inadequate or excessive accumulation of fibroblasts could result in abnormal tissue function. For example, the excess proliferation of fibroblasts contributes to the adventitial thickening observed during the development of hypoxia-induced pulmonary hypertension [2].

HPF from ScienCell Research Laboratories are isolated from human lung tissue. HPF are cryopreserved at primary culture ａnd delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HPF are characterized by immunofluorescent method with antibody to fibronectin. HPF are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi. HPF are guaranteed to further expand for 15 population doublings at the conditions provided by ScienCell Research Laboratories.

Reference
[1] Kuwano K, Hagimoto N, Hara N. （2001） Molecular mechanisms of pulmonary fibrosis ａnd current treatment. Curr Mol Med 1（5）:551-73.
[2] Das M, Dempsey EC, Reeves JT, Stenmark KR. （2004） Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia. Am J Physiol Lung Cell Mol Physiol 282（5）:L976-86