名稱: CCL13

純度:> 95 %

宿主:Yeast

種屬:Human

生物活性:

Testing in progress

蛋白構建:

A DNA sequence encoding human CCL13 (NP_005399.1) (Gln24-Thr98) was expressed with a polyhistidine tag at the C-terminus.

分子量:

The recombinant human CCL13 consists of 85 amino acids and predicts a molecular mass of 10 KDa. It migrates as an approximately 14 KDa band in SDS-PAGE under reducing conditions.

CCL13/MCP-4是CC家族趨化因子，是嗜酸性細胞、嗜堿性細胞、單核細胞、巨噬細胞、未成熟樹突狀細胞和T細胞的趨化因子，通過對上皮細胞、肌肉細胞和內皮細胞的作用，誘導關鍵的免疫調節反應。與其他CC趨化因子相似，CCL13與幾個趨化因子受體(CCR1、CCR2和CCR3)結合，使其對靶細胞產生不同的作用。

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CCL13  Background Information：

Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chemokines, CCL13 binds to several chemokine receptors (CCR1, CCR2 and CCR3), allowing it to elicit different effects on its target cells. A number of studies have shown that CCL13 is involved in many chronic inflammatory diseases, in which it functions as a pivotal molecule involved in the selective recruitment of cell lineages to the inflamed tissues and their subsequent activation. MCP-4/CCL13 is secreted from chondrocytes and activates the proliferation of rheumatoid synovial cells, thereby leading to joint destruction in RA. The interferon-gamma in combination with interleukin-1beta/tumor necrosis factor-alpha activates the production of MCP-4/CCL13 from chondrocytes in RA joints, and that secreted MCP-4/CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated kinase mitogen-activated protein kinase cascade. CCL13 may have some role in the pathogenesis of systemic sclerosis (SSc).