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CAS No. : 320-67-2

MCE 國際站：5-Azacytidine

產品活性：5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) 是胞苷核苷類似物，特異型抑制 DNA 甲基化。5-Azacytidine 與 DNA 結合共價捕獲 DNA甲基轉移酶 (DNA methyltransferases)，有益于逆轉表觀遺傳變化。5-Azacytidine 誘導細胞自噬 (autophagy)。

研究領域：Cell Cycle/DNA Damage  |  Epigenetics  |  Autophagy

作用靶點：Nucleoside Antimetabolite/Analog  |  DNA Methyltransferase  |  Autophagy

In Vitro: Unmethylated CpG islands associated with a variety of genes become partially or fully methylated in tumors and can be reactivated by 5-Azacytidine. 5-Azacytidine acts as weak inducers of erythroid differentiation of Friend erythroleukemia cells in the same concentration range where they affect DNA methyltransferase activity. 5-Azacytidine inhibits L1210 cells with ID₅₀ and ID₉₀ values of 0.019 and circa 0.15 μg/mL, respectively.

In Vivo: TdR-³H incorporation is significantly inhibited when the animals are exposed to 5-Azacitidine (100 mg/kg, i.p.) for 2 hr or longer.

相關產品：FDA-Approved Drug Library Plus  |  Covalent Screening Library Plus  |  Drug Repurposing Compound Library  |  Reprogramming Compound Library  |  FDA-Approved Drug Library Mini  |  Anti-Aging Compound Library  |  Covalent Screening Library  |  Anti-COVID-19 Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Antibiotics Library  |  Cell Cycle/DNA Damage Compound Library  |  Drug Repurposing Compound Library Plus  |  Epigenetics Compound Library  |  Bioactive Compound Library Plus  |  Autophagy Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  5-Fluorouracil  |  Gemcitabine  |  Decitabine  |  Cytarabine  |  5-BrdU  |  Capecitabine  |  Fludarabine  |  Forodesine hydrochloride  |  RG108  |  Guadecitabine sodium  |  Adenosine  |  Bobcat339 hydrochloride  |  SGI-1027  |  Zebularine  |  Dacarbazine  |  Trifluridine/tipiracil hydrochloride mixture  |  Floxuridine  |  Raltitrexed  |  6-Thioguanine  |  Lomeguatrib  |  Vidarabine  |  8-Azaguanine  |  Hinokitiol  |  Clofarabine  |  Carmofur  |  Doxifluridine  |  Tegafur

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