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Asenapine maleateCAS No. : 85650-56-2
MCE 國際站：Asenapine maleate
產品活性：Asenapine maleate是 5-HT(1A, 1B, 2A, 2B, 2C, 5A, 6, 7) 和 D2 的拮抗劑，Ki 值分別為 0.03-4.0 nM, 1.3 nM。同時也是一種抗精神病藥物。
研究領域：GPCR/G Protein | Neuronal Signaling
作用靶點：5-HT Receptor
In Vitro: Relative to its D2 receptor affinity, asenapine has a higher affinity for 5-HT2C, 5-HT2A, 5-HT2B, 5-HT7, 5-HT6, α2B and D3 receptors, suggesting stronger engagement of these targets at therapeutic doses. Asenapine behaves as a potent antagonist (pKB) at 5-HT1A (7.4), 5-HT1B (8.1), 5-HT2A (9.0), 5-HT2B (9.3), 5-HT2C (9.0), 5-HT6 (8.0), 5-HT7 (8.5), D2 (9.1), D3 (9.1), α2A (7.3), α2B (8.3), α2C (6.8) and H1 (8.4) receptors.
In Vivo: Asenapine is an atypical antipsychotic that is currently available for the treatment of schizophrenia and bipolar I disorder. Asenapine may have superior therapeutic effect on anxiety symptoms than other agents in rats. Asenapine has anxiolytic-like effects in the EPM and the defensive marble burying tests in mice.
相關產品：FDA-Approved Drug Library Plus | Drug Repurposing Compound Library | FDA-Approved Drug Library Mini | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library Plus | Bioactive Compound Library Plus | FDA Approved & Pharmacopeial Drug Library | Chlorpromazine hydrochloride | Serotonin hydrochloride | Harmine | SCH-23390 hydrochloride | Risperidone | Thioridazine hydrochloride | Aripiprazole | Olanzapine | Pimavanserin | Sertindole | Pindolol | SB-269970 hydrochloride | Brexpiprazole | Ketanserin | WAY-100635 maleate salt | Alprenolol hydrochloride | Lumateperone tosylate | Nefazodone hydrochloride | RU 24969 | Cariprazine hydrochloride | Puerarin | Quetiapine | Rupatadine Fumarate | Trazodone hydrochloride | CP-809101 hydrochloride | Naratriptan hydrochloride | Cisapride | Flibanserin | (Z)-Thiothixene
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