 |
|
|||||||||||||||||||||||||||||||||
| [發表評論] [本類其他產品] [本類其他供應商] [收藏] | ||||||||||||||||||||||||||||||||||
| 銷售商： 上海皓元生物醫藥科技有限公司 | 查看該公司所有產品 >> |
MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務。
Synucleozid hydrochlorideCAS No. :
MCE 國際站：Synucleozid hydrochloride
產品活性：Synucleozid (NSC 377363) 是可編碼 α-突觸核蛋白的 SNCA mRNA 的有效抑制劑 (IC50=1.5 μM)。Synucleozid 選擇性靶向 α-synuclein mRNA 的 5'UTR的 IRE 位點，減少了加載到多核糖體中的 SNCA mRNA 的量，從而抑制了α-synuclein 蛋白的翻譯。Synucleozid 有潛力用于帕金森病的相關研究。
作用靶點：DNA/RNA Synthesis
In Vitro: Synucleozid (0.25-1 μM; 24 hours) abrogates cytotoxicity induced by α-synuclein preformed fibrils, which act as seeds and recruit endogenous α-synuclein to aggregate.
Synucleozid (0-1 μM; 24 hours) binds to the A bulge near the base of the IRE hairpin, reduced levels of α-synuclein in a dose-dependent manner with an IC50 of 500 nM, and inhibits α-synuclein protein expression in SH-SY5Y neuroblastoma cells.
Synucleozid (100 nM-100 μM; 24 hours) binds to 2-AP-labeled and native IRE RNA with similar affinities. It decreases 2-AP emission with an EC50 value of 2.7 μM, recovery of 2-AP emissions is observed as a function of unlabeled SNCA IRE RNA (RNA-0) concentration, affording a competitive Kd of 1.5 μM.
Synucleozid (0.25-1 μM; 24 hours) decreases α-synuclein and other proteins that have IREs in their mRNA’s UTR including APP, PrP, Ferritin and TfR as a dose-dependent mannner. All panels is completed in SH-SY5Y cells, except for PrP protein which is assessed in Neuro-2A cells.
相關產品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Anti-Aging Compound Library | Oxaliplatin | Gemcitabine | Bleomycin sulfate | Carboplatin | Cytarabine | Favipiravir | Methotrexate | Streptozocin | Anisomycin | Thymidine | Fludarabine | Epirubicin hydrochloride | Daunorubicin hydrochloride | Capecitabine | Hydroxyurea | Plicamycin | Urolithin A | ML216 | Folic acid | Brequinar | Halofuginone | Triciribine | Floxuridine | Galidesivir hydrochloride | Adenine | Dihydromyricetin | GC7 Sulfate
品牌介紹:
• MCE (MedChemExpress) 擁有數百種全球獨家化合物，我們致力于為全球科研客戶提供最新最全的高品質小分子活性化合物；
• 10,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領域；
• 設有專業的實驗中心和嚴格的質控、驗證體系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產品的高純度、高品質；
• 產品的生物活性多經各國客戶實驗驗證；
• Nature, Cell, Science 等多種頂級期刊及制藥專利收錄了MCE客戶的科研成果；
• 專業團隊跟蹤最新的制藥及生命科學研究進展，為您提供全球最新的活性化合物；
• 與世界各大制藥公司及知名科研機構建立了長期的合作。
