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M344

CAS No. : 251456-60-7

MCE 國(guó)際站：M344

產(chǎn)品活性：M344 (D 237) 是一種組蛋白去乙酰化酶抑制劑，IC₅₀ 為 100 nM。

研究領(lǐng)域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶點(diǎn)：HDAC

In Vitro: M344 is a potential histone deacetylase (HDAC) inhibitor. With increasing concentrations of M344, there is a dose dependant decrease in BRCA1 mRNA and treatment with both 1 and 5 μM concentrations of M344 resulting in a significant decrease in BRCA1 expression in all cell lines examined. M344 in combination with Cisplatin leads to a decrease in BRCA1 mRNA expression as compared to Cisplatin treatment alone in all cell lines with the exception of A2780s, which is recognized as having potent cytotoxicity to Cisplatin. In the MCF7 cell line, BRCA1 is down regulated at physiological doses of M344 (0.5 μM and 1 μM) but M344 does not have the same inhibitory effect on BRCA1 at the 5.0 μM dose. Co-treatment with Cisplatin and increasing concentrations of M344 reduces BRCA1 protein levels in all breast and ovarian cell lines examined.

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