曉東宜健(蘇州)儀器設備有限公司延承了自2004年提出的建設仿生體外消化吸收系統的概念,在澳大利亞Monash大學創建的“準真實”體外人胃系統和小鼠胃系統的基礎上不斷改良與完善,研發出一系列多樣性的仿生消化系統。
許多食品、益生菌產品、口服醫藥等的研發過程里都需要有效的體外實驗。通過建立和器官“高度相似”的設備,實現相應的生理機能,可以開展與醫學相關的科學實驗研究,協助理解消化道里的現象,從而達到體內實驗難以實現的科研目標。
我們越來越意識到食品、藥品在體內的“加工”過程與在體外的生產過程同樣重要,甚至更為重要。體內消化吸收的過程及效率、消化系統內部的環境特征變化、腸道菌群的數量、種類、狀態等,最終與我們是“三高”或是“忽高忽低”等都有直接的聯系。食品營養健康也是個化學工程問題,例如:某食品進入體內后多長時間才能被消化分解,這個過程中又有哪種元素被吸收率較大或是無法被吸收,多種元素混合后將產生什么樣的化學反應是否會導致消化不良......想要得出以上結論,需要解析人體內部的“化工過程”。同時,為了減少某些動物實驗,曉東宜健結合化學工程、材料工程、機電工程、食品工程、醫藥工程、解剖學等締造了一個接近真實的體外消化吸收檢測系統。這樣的產品可以助力體內現象的觀察研究、幫助相關健康產品的開發、開展產品的測試等有意義的活動。
食品、口服藥對我們的生活質量Life Quality (LQ) 有著巨大的影響。大量的前期實驗是必要的。曉東宜健系列設備,在減少大量動物實驗的同時,將使食品醫藥產業感受到“如虎添翼”。
當然,人類提高了自身生活質量的同時,也需要關注其他物種如何更科學地被保護或者更合理地被人類“利用”。飼料業的發展同樣需要優秀、真實的體外消化吸收的監測系統。曉東宜健認為牛要有針對牛的高度仿生消化系統、豬要有豬的專門系統,魚要有魚的系統等等,以此類推。不同物種消化系統的規模、特點不一樣,同一種“小白鼠”不可能達到不同生物實驗的要求。
曉東宜健原創研發的“準器官”或“準真實”仿生體外消化系統的系列產品經過十幾年的研究與磨礪,為不少科研機構、高校及企業提供了幫助。曉東宜健不會停止“開啟未來”的腳步,將繼續努力地、創造性地為人類生活質量工程(LQE)領域做最好的貢獻。
Xiao Dong Pro-health (Suzhou) Instrumentation Co Ltd has been established based on an idea of biology-inspired chemical engineering created in 2004 at Auckland (New Zealand) and has now substantially extended the early primitive devices constructed for research at Monash University (Australia). These were considered as the Bio-mimic In Vitro Digestion-Absorption Systems. The human system and rat system, and a variety of related devices of different generations have been developed over these many years. Today, a range of modern devices are manufactured at the company.
In the development of functional foods including probiotics containing foods, and orally delivered medicines, etc., it is advantageous to have effective in vitro systems to perform pre-clinical experiments. Through designing and constructing realistic devices, realizing the desired physiological functions, one can progress on excellent scientific studies. The technology provides a Technical Platform for fundamental studies as well as product developments. These help understanding what is going on in the digestive tracks, realizing the objectives that are extremely difficult in vivo. The company laboratory is providing a range of testing services, which help achieve research goals and product development goals. Companies in food, pharmaceutical fields and universities are our usual clients.
How to create a relevant in vitro system that can reflect as close as possible the real situation? This has been a great challenge. The original idea here was that one could follow closely the anatomies of human and animals (geometrically, mechanically and biochemically) to make ‘organs’ of interest. Then, a range of mechanical, electrical and electronics, and computer programming aspects have to come in together to ensure the motility and functionality of the in vitro system(s) realistic. The designs can be age-dependent like child and adult. An effective in vitro system can help reducing the number of animals slaughtered for in vivo tests.
In addition to bio-mimic human systems, different animals due to their distinct differences in anatomies and functions in general should have their corresponding in vitro systems. These are relevant perhaps for developing animal feeds (stock foods or pet foods) etc. The company has established a general methodology to design and construct animal specific devices, chicken, pig, fish or even cow.
Through these years of developments and hard-working, rather realistic systems are available. The company is aiming at Improving Life Quality of People through its unique technologies and its future innovations. LQ essentially. We all know IQ and EQ are important qualities of an individual. LQ, on the other hand, is valid for everybody. The company is pushing forward with even greater ideas ahead.